The prediction of progression-free and overall survival in women with an advanced stage of epithelial ovarian carcinoma
Objective: Prognosis in women with ovarian cancer mainly depends on International Federation of Gynecology and Obstetrics stage and the ability to perform optimal cytoreductive surgery. Since ovarian cancer has a heterogeneous presentation and clinical course, predicting progression-free survival (PFS) and overall survival (OS) in the individual patient is difficult. The objective of this study was to determine predictors of PFS and OS in women with advanced stage epithelial ovarian cancer (EOC) after primary cytoreductive surgery and first-line platinum-based chemotherapy. Design: Retrospective observational study. Setting: Two teaching hospitals and one university hospital in the south-western part of the Netherlands. Population: Women with advanced stage EOC. Methods: All women who underwent primary cytoreductive surgery for advanced stage EOC followed by first-line platinum-based chemotherapy between January 1998 and October 2004 were identified. To investigate independent predictors of PFS and OS, a Cox' proportional hazard model was used. Nomograms were generated with the identified predictive parameters. Main outcome measures: The primary outcome measure was OS and the secondary outcome measures were response and PFS. Results: A total of 118 women entered the study protocol. Median PFS and OS were 15 and 44 months, respectively. Preoperative platelet count (P = 0.007), and residual disease <1 cm (P = 0.004) predicted PFS with a optimism corrected c-statistic of 0.63. Predictive parameters for OS were preoperative haemoglobin serum concentration (P = 0.012), preoperative platelet counts (P = 0.031) and residual disease <1 cm (P = 0.028) with a optimism corrected c-statistic of 0.67. Conclusion: PFS could be predicted by postoperative residual disease and preoperative platelet counts, whereas residual disease, preoperative platelet counts and preoperative haemoglobin serum concentration were predictive for OS. The proposed nomograms need to be externally validated.
|Keywords||Blood platelets, Haemoglobin, Nomogram, Ovarian carcinoma, Overall survival, Prediction model, Progression-free survival, Surgical cytoreduction|
|Persistent URL||dx.doi.org/10.1111/j.1471-0528.2008.02033.x, hdl.handle.net/1765/14976|
|Journal||BJOG: An International Journal of Obstetrics and Gynaecology|
Gerestein, C.G, Eijkemans, M.J.C, de Jong, D, van der Burg, M.E.L, Dykgraaf, R.H.M, Kooi, G.S, … Ansink, A.C. (2009). The prediction of progression-free and overall survival in women with an advanced stage of epithelial ovarian carcinoma. BJOG: An International Journal of Obstetrics and Gynaecology, 116(3), 372–380. doi:10.1111/j.1471-0528.2008.02033.x