Objective: To study associations between maternal dietary and supplement intake of antioxidants vitamin E, retinol and congenital heart defects (CHDs). Design: Case-control study. Setting: Erasmus MC, University Medical Center Rotterdam, the Netherlands. Population: Participants were 276 case mothers of a child with CHD and 324 control mothers with their children. Methods: Food frequency questionnaires covering the intake of the previous 4 weeks were filled out at 16 months after the index pregnancy. Data were compared between cases and controls using the Mann-Whitney U test. Risk estimates for the association between CHD and dietary intake of vitamin E and retinol were estimated in a multivariable logistic regression model. Main outcome measures: Medians (5-95th percentile) and odds ratios with 95% CI. Results: Dietary vitamin E intake was higher in case mothers than in controls, 13.3 (8.1-20.4) and 12.6 (8.5-19.8) mg/day (P = 0.05). CHD risk increased with rising dietary vitamin E intakes (P-trend = 0.01). Periconception use of vitamin E supplements in addition to a high dietary vitamin E intake above 14.9 mg/day up to nine-fold increased CHD risk. Retinol intakes were not significantly different between the groups and not associated with CHD risk. Conclusions: High maternal vitamin E by diet and supplements is associated with an increased risk of CHD offspring.

Additional Metadata
Keywords Antioxidants, Heart anomalies, Nutrients, Risk factors
Persistent URL dx.doi.org/10.1111/j.1471-0528.2008.01957.x, hdl.handle.net/1765/14988
Citation
Smedts, H.P.M, de Vries, J.H, Rakhshandehroo, M, Wildhagen, M.F, Verkleij-Hagoort , A.C, Steegers, E.A.P, & Steegers-Theunissen, R.P.M. (2009). High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG: An International Journal of Obstetrics and Gynaecology, 116(3), 416–423. doi:10.1111/j.1471-0528.2008.01957.x