Antibody response after influenza immunization with various vaccine doses
a double-blind, placebo-controlled, multi-centre, dose-response study in elderly nursing-home residents and young volunteers
The dose effect (0, 10, 20 and 60 micrograms) of influenza subunit vaccine on the antibody response was investigated in nursing-home residents and young controls. The vaccine antigens were: A/Taiwan/1/86 (H1N1), A/Sichuan/2/87 (H3N2) and B/Beijing/1/87. For the influenza B antigen, the post-GMT and the 'percentage protective titre' increased significantly both in the young controls and nursing-home residents. No dose effect was observed for the A/Taiwan, and a minor dose effect for A/Sichuan. All vaccine doses were well tolerated by both groups. We conclude from our data that higher vaccine doses may result in a better antibody response against some antigens but not against others. Therefore, in general, increasing the vaccine dose is no adequate method to improve the antibody response.
|Keywords||Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral/*biosynthesis, Antigens, Viral/administration & dosage, Dose-Response Relationship, Immunologic, Double-Blind Method, Female, Humans, Influenza A virus/immunology, Influenza B virus/immunology, Influenza Vaccines/*administration & dosage/adverse effects, Male, Middle Aged, Nursing Homes|
|Persistent URL||dx.doi.org/10.1016/0264-410X(93)90333-S, hdl.handle.net/1765/14998|
Palache, A.M., Beyer, W.E.Ph., Sprenger, M.J.W., Masurel, N., de Jonge, S., Vardy, A., … Rubinstein, E.. (1993). Antibody response after influenza immunization with various vaccine doses. Vaccine, 11(1), 3–9. doi:10.1016/0264-410X(93)90333-S