Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands
Objective: To assess whether pregnancy history can predict the occurrence of a spontaneous ongoing pregnancy in subfertile couples. Design: Prospective cohort study. Setting: Thirty fertility centers in the Netherlands. Patient(s): Subfertile, ovulatory women with at least one patent tube and male partners without severely impaired semen quality. Intervention(s): Fertility work-up, including a detailed pregnancy history. Main Outcome Measure(s): Spontaneous ongoing pregnancy. Result(s): We included 4445 couples, of whom 793 (18%) had a spontaneous ongoing pregnancy within 1 year of follow-up. Previous live birth and miscarriage in current partnership were both associated with higher fecundity as compared with primary infertility (hazard rate ratios for spontaneous pregnancy [HR] 1.4; 95% CI, 1.2-1.7 and 1.3; 95% CI, 1.0-1.5, respectively). Pregnancies in a woman's previous partnerships did not affect the fecundity of the couple. A pregnancy in a previous partnership of the male partner was associated with lower fecundity (HR 0.76; 95% CI, 0.58-0.99). A previous pregnancy after fertility treatment also was associated with lower fecundity (HR 0.52; 95% CI, 0.30-0.90). Conclusion(s): Accurate prediction of the future fertility of a couple requires an exact assessment of the fertility history of both partners.
|Keywords||Fertility history, Netherlands, adult, article, controlled study, female, fertility, human, infertility, major clinical study, male, parthenogenesis, pregnancy, priority journal, prognosis, prospective cohort, secondary subfertility, spontaneous pregnancy, subfertility|
|Persistent URL||dx.doi.org/10.1016/j.fertnstert.2007.07.1301, hdl.handle.net/1765/15216|
van der Steeg, J.W, Steures, P, Eijkemans, M.J.C, Habbema, J.D.F, Hompes, P.G, Michgelsen, H.W.B, … Mol, B.W.J. (2008). Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands. Fertility and Sterility, 90(3), 521–527. doi:10.1016/j.fertnstert.2007.07.1301