Histogram-based selective deblurring to improve computed tomography imaging of calcifications
OBJECTIVES: Computed tomography (CT) imaging of small high-density structures, eg, calcifications, is hampered by image blur. This study aims to deconvolve calcifications in the transverse and longitudinal directions while avoiding noise amplification and edge-ringing artifacts in the surrounding low-density structures. MATERIALS AND METHODS: A method referred to as histogram-based selective deblurring (HiSD) has been developed to generate a restored image by combining the low-intensity (ie, Hounsfield Units) information of the original image with the high-intensity information of the deconvolved image. HiSD is evaluated on phantom and in vitro atherosclerotic plaque CT images by comparing the original and restored images with their corresponding reference micro-CT images both qualitatively and quantitatively. RESULTS: HiSD reduces calcification blur in the transverse and longitudinal directions without introducing noise and ringing-artifacts in the surrounding tissues. Calcification area and volume measurements are significantly improved in the restored images (reducing on average overestimation by 32% and 83%, respectively). CONCLUSIONS: HiSD significantly improves CT visualization and quantification of small high-density structures imaged in vitro.
|Keywords||*Tomography, X-Ray Computed, Algorithms, Atherosclerosis/*radiography, Calcinosis/*radiography, Humans, Imaging, Three-Dimensional, Phantoms, Imaging, Radiographic Image Enhancement/*methods, Reproducibility of Results|
|Persistent URL||dx.doi.org/10.1097/01.rli.0000248894.94242.96, hdl.handle.net/1765/15442|
Rollano Hijarrubia, M.E., Niessen, W.J., Weinans, H.H., van der Lugt, A., & Stokking, R.. (2007). Histogram-based selective deblurring to improve computed tomography imaging of calcifications. Investigative Radiology: a journal of clinical and laboratory research, 42(1), 8–22. doi:10.1097/01.rli.0000248894.94242.96