Purpose One-fourth of the patients with exudative age-related macular degeneration (AMD) treated with an autologous retinal pigment epithelium (RPE)-choroid translocation had a hyperfluorescent optic disc with indocyanine green angiography (ICGA). This study aimed to identify whether indocyanine green (ICG)-assisted surgery was related to the hyperfluorescence of the optic disc with ICGA.MethodsRetrospective observational case series of 31 AMD patients treated with an RPE-choroid translocation and who had ICGA after surgery. The ICGAs were assessed for hypo/iso/hyperfluorescence of the optic disc and fluorescence was related to the time interval between ICGA and the possible use of intravitreal ICG.ResultsThe optic disc was hyperfluorescent in six patients, isofluorescent in one, and hypofluorescent in 24 patients. All hyperfluorescent optic discs and 7 of the 24 hypofluorescent optic discs were preceded with ICG-assisted surgery with a time interval of 7±3 weeks and 43±12 weeks, respectively (P=0.001, Student t-test). The other 17 hypofluorescent discs were not preceded by ICG-assisted surgery and the one isofluorescent optic disc was observed 32 weeks after ICG-assisted surgery.ConclusionThere was a statistically significant correlation between intravitreal ICG use during surgery and a hyperfluorescent optic disc with ICGA in our patient group.

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Keywords article, clinical article, controlled study, fluorescence, human, indocyanine green, indocyanine green angiography, optic disk anomaly, optic disk hyperfluorescence, pigment epithelium, retina detachment, retina macula age related degeneration
Persistent URL dx.doi.org/10.1038/eye.2008.146, hdl.handle.net/1765/16425
Maaijwee, K.J.M., van den Biesen, P.R., & van Meurs, J.C.. (2009). Hyperfluorescence of the optic disc with indocyanine green angiography. Eye, 23(4), 819–821. doi:10.1038/eye.2008.146