Hepatic Lipase: Regulation at the post-transcriptional level
Hepatic lipase is synthesized and constitutively secreted by liver parenchymal cells (1-3), and is subsequently bound extracellularly in the space of Disse of the liver (4-6). The protein is also found in adrenals, ovaries and testes (7-10). However, in adrenals and ovaries an altered, shorter mRNA is expressed and no mature HL protein is synthesized (3, 9, 11, 12). Thus, liver parenchymal cells may uniquely synthesize and secrete a fully active HL. HL affects the metabolism of several lipoproteins and is thought to protect against the development of atherosclerosis (Chapter 1.1.1). Therefore it is of importance to understand the mechanisms which regulate HL expression. Several cell types serve as a model system for secretion ofHL (13-17). The studies described herein were performed with the human-derived HepG2 cell-line and freshly isolated rat hepatocytes.
|Publisher||Erasmus MC: University Medical Center Rotterdam|
|Promotor||Jansen, H. (Hans)|
|Sponsor||Netherlands Heart Foundation, Novo Nordisk|
|Keywords||hepatic lipase, lipoproteins, liver diseases|
Neve, B.P.. (1998, May 15). Hepatic Lipase: Regulation at the post-transcriptional level. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/17607