Chromatin dynamics and the regulation of B-glohin gene expression
The human B-globin locus is frequently used as a model system to study mechanisms controlling tissue-specific and developmentally regulated gene expression. Much of the recent progress in understanding the regulation of B-globin gene expression has come from a better knowledge of the process of transcription. Proper transcriptional regulation of the human B-globin genes occurs, at least in part, through specific interactions of regulatory traus-acting proteins to defined cis-regulatory sequences that include promoters, enhancers, silencers, and elements of the locus control region.
|Keywords||B-globin, gene expression, molecular genetics|
|Promotor||Grosveld, F.G. (Frank)|
|Publisher||Erasmus University Rotterdam|
Wijgerde, M.G.J.M.. (1998, June 10). Chromatin dynamics and the regulation of B-glohin gene expression. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17661