Reptides and Proteins Interacting with the Androgen Receptor
Androgens are important sex steroid hormones. The androgens testosterone and dihydrotestosterone (DHT) are essential for normal male sexual differentiation and for the development and maintenance of male reproductive tissues, including the prostate. Androgens mediate their effects by binding to, and activation of, the androgen receptor (AR), which is a transcription factor belonging to the nuclear receptor (NR) family. Upon androgen binding, the AR is able to recognize specific DNA sequences from where it regulates the expression of its target genes. A disregulated androgen-AR pathway is involved in several diseases, such as prostate cancer, androgen insensitivity syndrome (AIS), and Kennedy’s disease or spinal and bulbar muscular atrophy (SBMA).
|Keywords||Androgen receptor, DNA, cancer, proteins, reptides, testosterone|
|Promotor||Trapman, J. (Jan)|
|Publisher||Erasmus University Rotterdam|
|Sponsor||Dutch Cancer Society (KWF) Schering-Plough Laagland BV, Stichting Wetenschappelijk Onderzoek Prostaatkanker (SWOP)|
van de Wijngaart, D.J.. (2009, April). Reptides and Proteins Interacting with the Androgen Receptor. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17785