Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies
The 14-3-3 protein test has been shown to support the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) when associated with an adequate clinical context, and a high differential potential for the diagnosis of sporadic CJD has been attributed to other cerebrospinal fluid (CSF) proteins such as tau protein, S100b and neuron specific enolase (NSE). So far there has been only limited information available about biochemical markers in genetic transmissible spongiform encephalopathies (gTSE), although they represent 10-15% of human TSEs. In this study, we analyzed CSF of 174 patients with gTSEs for 14-3-3 (n = 166), tau protein (n = 78), S100b (n = 46) and NSE (n = 50). Levels of brain-derived proteins in CSF varied in different forms of gTSE. Biomarkers were found positive in the majority of gCJD (81%) and insert gTSE (69%), while they were negative in most cases of fatal familial insomnia (13%) and Gerstmann-Sträussler-Scheinker syndrome (10%). Disease duration and codon 129 genotype influence the findings in a different way than in sporadic CJD.
|Keywords||14-3-3 protein, CSF proteins, Creutzfeldt Jakob disease, Creutzfeldt-Jakob disease, Gerstmann Straussler Scheinker syndrome, Tau, adult, aged, article, biological marker, cerebrospinal fluid, cerebrospinal fluid analysis, controlled study, disease duration, fatal familial insomnia, female, genotype, human, major clinical study, male, neuron specific enolase, prion disease, priority journal, protein 14 3 3, protein S100B, sensitivity analysis, tau protein|
|Persistent URL||dx.doi.org/10.1007/s00415-009-5163-x, hdl.handle.net/1765/17945|