Aim To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT).Methods and resultsThirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slices. Delayed-enhanced MRI was performed for scar analysis. Echocardiography was used to determine response to CRT (reduction ≥15% in LV end-systolic volume 6 months after implantation). At follow-up, 21 patients (60%) were classified as responders. On MRI, SDt-16 was significantly higher in responders compared with non-responders (median 97 vs. 60 ms, P < 0.001), whereas the total extent of scar was larger in non-responders (median 35% vs. 3% in responders, P < 0.001). At the logistic regression analysis, SDt-16 was directly associated (OR = 6.3, 95% CI 3.1-9.9, P < 0.001) and the total extent of scar was inversely associated (OR = 0.52, 95% CI 0.43-0.87, P < 0.001) with response to CRT.ConclusionMagnetic resonance imaging offers the unique opportunity to assess LV dyssynchrony and scar extent in a single session. Both these parameters are important predictors of echocardiographic response to CRT.

Additional Metadata
Keywords Cardiac resynchronization therapy, Left ventricular dyssynchrony, Magnetic resonance imaging, Myocardial scar, adult, article, cardiac resynchronization therapy, clinical article, controlled study, female, heart failure, heart left ventricle ejection fraction, heart left ventricle enddiastolic volume, heart muscle, heart muscle conduction disturbance, heart volume, human, left ventricular dyssynchrony, left ventricular end systolic volume, male, myocardial scar, nuclear magnetic resonance imaging, priority journal, scar, treatment outcome
Persistent URL dx.doi.org/10.1093/eurheartj/ehp280, hdl.handle.net/1765/17948
Citation
Marsan, N.A, Westenberg, J.J.M, Ypenburg, C, van Bommel, R.J, Roes, S, Delgado, V, … Bax, J.J. (2009). Magnetic resonance imaging and response to cardiac resynchronization therapy: Relative merits of left ventricular dyssynchrony and scar tissue. European Heart Journal, 30(19), 2360–2367. doi:10.1093/eurheartj/ehp280