Primitive progenitor cells in human acute myeloid leukemia : studies in immunodeficient mice and in long-term bone marrow culture

Acute myeloid leukemia is a malignant clonal proliferation of immature hematopoietic cells. Leukemic blasts may express abilities for maturation to a variable degree, which leads to morphological heterogeneity. Generally the transformed leukemic stem cell is committed to the granulocytic lineage. Sometimes a predominance of blast cells from the erythroid or megakaryocytic lineage may be observed. The leukemic transformation may occur at the level of a pluripotent or a less primitive hematopoietic cell. This is apparent from the observation of clonal markers, e.g. unique cytogenetic abnormalities in single versus several blood cell lineages.

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