Predictive value of pharmacodynamic parameters of antimicrobial agents
The study of the phamlacodynamicg of antimicrobial agents has been a rapidly developing line of research in recent years. Regarding this line of research it is important to appreciate the difference between the pharmacokinetics and the phannacodynamics of phamlaceutical agents. Pharmacokinetics describes the processes that take place in a human or animal body with a drug after a drug has been administered; it describes the concentration profile of the drugs in serum, in tissues, other body fluids and at the site of infection in relation to the dosing regimen used. Pharmacodynamics takes the concentration profiles of the drugs in body fluids, tissues and at the site of the infections into account and in the case of antimicrobial agents describes their effect on the infection or the bacterial population over time. Furthemlore, it also describes other pharmacologic effects of the drugs, including their toxic effects on host cells and tissues.
|Publisher||Erasmus MC: University Medical Center Rotterdam|
|Promotor||Verbrugh, H.A. (Henri)|
|Sponsor||Abbott B.V., Astra Pharmaceutica B.V. Bayer B.V., Biorad Laboratories B.V., Eli Lily Nederland B.V., Glaxo Welcome B.V., Hoechst Marion Roussel B.V., Leo Phann8ceutical B.V., Novo Nordisk Fanna B.V., Parke·Davis B.V., Pfizer B.V.,Pharmacia & Upjohn B.V., Rhone Poulenc Rorer B.V., Zeneca B.V.|
den Hollander, J.G.. (1999, March 17). Predictive value of pharmacodynamic parameters of antimicrobial agents. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/19749