Chromatin Structure in Cell Differentiation, Aging and Cancer
Chromatin is the structure that the eukaryotic genome is packaged into, allowing over a metre of DNA to fit into the small volume of the nucleus. It is composed of DNA and proteins, most of which are histones. This DNA-protein complex is the template for a number of essential cell processes including transcription and replication. The basic structural unit of chromatin is the nucleosome. Nucleosomes comprise around 146 base pairs of DNA wrapped in a left-handed superhelix 1.7 times around a core histone octamer. This 11nm fibre is often referred to as ‘beads on a string’. Chromatin assembly involves wrapping of DNA around histone octameres producing repetitive nucleosomal array followed by folding of chromatin fibre into solenoid-like structure and deposition of non-histone proteins.
|Keywords||aging, cancer, cell differentiation, chromatine, molocular biology|
|Promotor||Verrijzer, C.P. (Peter)|
|Sponsor||EC, EMC, SSCD|
|Publisher||Erasmus MC: University Medical Center Rotterdam|
Kheradmand Kia, S.. (2009, June 3). Chromatin Structure in Cell Differentiation, Aging and Cancer. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/20469
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