2010-09-24
Clinical effects of proton pump inhibitors: Focus on pharmacogenetics, kinetics and dynamics
Publication
Publication
Klinische effecten van proton pomp remmers: Focus op farmacogenetica, kinetiek en dynamiek
This thesis describes the clinical effects of proton pump inhibitors, with focus on pharmacogenetics, kinetics and dynamics. The aims were to investigate the occurence of Rebound Acid Hypersecretion and to investigate the speed of onset, the duration of effect and the difference in acid-inhibition between esomeprazole, rabeprazole and pantoprazole. Furthermore the prevalence of CYP2C19 polymorphism was studied in a Caucasian population. The influence of CYP2C19 polymorphism on acid-inhibition and pharmacokinetics of proton pump inhibitors in Caucasians was also studied.
| Additional Metadata | |
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| , , , , , , , , , , , , | |
| Apotheek Haagse Ziekenhuizen, AstraZeneca B.V., Bayer Schering Pharma, Fresenius-Kabi B.V., HagaZiekenhuis, Inge Voesten-Appel stichting, Nederlandse Vereniging voor Gastroenterologie | |
| E.J. Kuipers (Ernst) | |
| Erasmus University Rotterdam , Haga Ziekenhuis, Den Haag | |
| hdl.handle.net/1765/21086 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Hunfeld, N. (2010, September 24). Clinical effects of proton pump inhibitors: Focus on pharmacogenetics, kinetics and dynamics. Retrieved from http://hdl.handle.net/1765/21086 |
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| Additional Files | |
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| stellingen N Hunfeld.pdf , 181kb | |
| 3158_Hunfeld, Nicole Geertruida Maria.jpg Cover Image , 25kb | |
