Absence epilepsy and periventricular nodular heterotopia
We report a case of a girl who presented with typical absence seizures at age of 4.5 years. EEG showed absence seizures of sudden onset with 3 Hz spike-and-waves that also correlated with the clinical absences. The seizure semiology included subtle deviation of the eyes which prompted MRI investigation of the brain. This showed a periventricular nodular heterotopia in the mid to anterior horn of the right lateral ventricle. Although possibly coincidental, periventricular heterotopia are considered to be epileptogenic and this association has been reported once before. Migration disorders, such as in the periventricular heterotopia of our patient, may influence the formation and excitability of the striato-thalamo-cortical network involved in the generation of 3 Hz spike-waves.
|Keywords||3 Hz spike-waves, Absence epilepsy, Cortex, Migration, Periventricular nodular heterotopia, Thalamus, absence, article, behavior change, case report, child, consciousness disorder, disease association, drug eruption, electroencephalogram, epileptic focus, ethosuximide, family history, female, follow up, human, lamotrigine, lateral brain ventricle, low drug dose, nuclear magnetic resonance imaging, periventricular heterotopia, preschool child, priority journal, side effect, spike wave, valproic acid|
|Persistent URL||dx.doi.org/10.1016/j.seizure.2010.06.013, hdl.handle.net/1765/21114|
de Wit, M.C.Y., Schippers, H.M., de Coo, I.F.M., Arts, W.F.M., Lequin, M.H., Brooks, A.S., … Mancini, G.M.S.. (2010). Absence epilepsy and periventricular nodular heterotopia. Seizure - European Journal of Epilepsy, 19(7), 450–452. doi:10.1016/j.seizure.2010.06.013