Partial Liquid Ventilation: Animal Studies on Lung Function

Various mechanical ventilation techniques have been investigated, both experimentally and clinically, to improve outcome from acute respiratory failure. As an alternative means of respiratory support, perfluorocarbon (PFC) liquids have gained Interest first in liquid breathing applications, and then have formed the basis for the liquid ventilation technique. Combining the liquid and gas ventilation techniques, a new ventilatory support technique, namely partial liquid ventilation, is In progress as an investigational treatment modality in which gas tidal ventilation is superimposed on PFC-treated lungs. This thesis consists of six articles focusing on this topic. One review and five articles describing original experimental work on partial liquid ventilation are presented. Partial liquid ventilation is Investigated with respect to its effects on pUlmonary gas exchange and respiratory system mechanics in an animal model of acute respiratory failure and in healthy animals.