Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus
Purpose: Plasma apolipoprotein M (apoM) is potentially anti-atherogenic, and has been found to be associated positively with plasma total, LDL and HDL cholesterol in humans. ApoM may, therefore, be intricately related to cholesterol metabolism. Here, we determined whether plasma apoM is affected by statin or fibrate administration in patients with diabetes mellitus. Methods: Fourteen type 2 diabetic patients participated in a placebo-controlled crossover study which included three 8-week treatment periods with simvastatin (40 mg daily), bezafibrate (400 mg daily), and their combination. Results: ApoM was decreased by 7% in response to simvastatin (P< 0.05 from baseline and placebo), and remained unchanged during bezafibrate and combined simvastatin. +. bezafibrate administration. Plasma apoM concentrations correlated positively with apoB-containing lipoprotein measures at baseline and during placebo (P< 0.02 to P< 0.001), but these relationships were lost during all lipid lowering treatment periods. Conclusions: This study suggests that, even though plasma apoM is lowered by statins, apoM metabolism is to a considerable extent independent of statin- and fibrate-affected pathways involved in cholesterol homeostasis.
|Keywords||Apolipoprotein B, Apolipoprotein M, Bezafibrate, HDL cholesterol, LDL cholesterol, Simvastatin, Type 2 diabetes, adult, apolipoprotein A1, apolipoprotein B, apolipoprotein M, article, atherosclerosis, bezafibrate, blood level, blood sampling, cholesterol, cholesterol metabolism, clinical article, clinical trial, controlled clinical trial, controlled study, crossover procedure, diabetes mellitus, diabetic patient, double blind procedure, fibric acid derivative, high density lipoprotein cholesterol, human, hydroxymethylglutaryl coenzyme A reductase inhibitor, hypercholesterolemia, low density lipoprotein cholesterol, metformin, non insulin dependent diabetes mellitus, placebo, plasma, priority journal, simvastatin, sulfonylurea derivative, treatment response|
|Persistent URL||dx.doi.org/10.1016/j.atherosclerosis.2010.07.048, hdl.handle.net/1765/21625|
Kappelle, P.J.W.H., Ahnström, J., Dikkeschei, B.D., de Vries, R., Sluiter, W.J., Wolffenbuttel, B.H.R., … Dullaart, R.P.F.. (2010). Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus. Atherosclerosis, 213(1), 247–250. doi:10.1016/j.atherosclerosis.2010.07.048