To demonstrate that pandemic (H1N1) 2009 virus may cause respiratory disease in cats, we intratracheally infected cats. Diffuse alveolar damage developed. Seroconversion of sentinel cats indicated cat-to-cat virus transmission. Unlike in cats infected with highly pathogenic avian influenza virus (H5N1), extrarespiratory lesions did not develop in cats infected with pandemic (H1N1) 2009 virus.

Additional Metadata
Keywords Netherlands, animal tissue, antibody titer, antigen expression, article, blood sampling, case report, child, controlled study, cytokeratin, experimental cat, female, histopathology, human, human tissue, influenza A (H1N1), lung infiltrate, lung injury, lymphocyte, lymphocytolysis, macrophage, neutrophil chemotaxis, nonhuman, pandemic influenza, pathogenesis, plasma cell, polymerase chain reaction, preschool child, reverse transcription, sinus histiocytosis, virus isolation, virus nucleoprotein
Persistent URL dx.doi.org/10.3201/eid1611.100845, hdl.handle.net/1765/21706
Citation
van den Brand, J.M.A., Stittelaar, K.J., van Amerongen, G., van de Bildt, M.W.G., Leijten, L.M.E., Kuiken, T., & Osterhaus, A.D.M.E.. (2010). Experimental pandemic (H1N1) 2009 virus infection of cats. Emerging Infectious Diseases (Print), 16(11), 1745–1747. doi:10.3201/eid1611.100845