Bone mineral mass and bone turnover parameters in osteoporosis

In the past decades osteoporosis has been recognized as an important public health problem. Several causes for this problem can be pointed out. The most probable cause for the development of osteoporosis is the loss of ovarian function in women and the increasing age of people, thereby increasing the incidence of osteoporosis. Other causes or risk factors for the development of osteoporosis are immobilization and dietary deficiencies. Finally, the outcome of osteoporosis is an increased risk for the development of fractures (chapter 1.3). The terminology associated with osteoporosis was developed in the nineteenth century by German pathologists to distinguish diseases of bone. Pommer stated in 1926 that in osteoporosis the formation of bone by osteoblasts was not able to replace the bone resorbed by osteoclasts. Pommer performed extensive histomorphometric analysis of bone, thereby distinguishing various forms of osteoporosis (senile, immobility), osteomalacia and osteitis fibrosa cystica.

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