Children and young adults born small for gestational age (SGA) : GH-IGF-IGFBP axis, insulin sensitivity, adipocytokines and body composition during and after growth hormone treatment

This doctoral thesis gives a detailed account of various studies, performed in short children born small for gestational age (SGA) participating in the third Dutch GH trial (IUGR-3 study), and in young SGA adults previously treated with GH in the first Dutch GH trial (SGA follow-up study). This chapter describes defi nitions of SGA, prevalence and etiology of SGA, and clinical and endocrinological aspects associated with SGA. Also the effects of GH treatment in short SGA subjects are discussed. Finally, the aims and outline of this thesis, inclusion and exclusion criteria and study designs of the IUGR-3 study (appendix A), IUGR-1 study (appendix B) and SGA follow-up study (appendix C) are presented.

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