Small cell lung cancer (SCLC) is the lung neoplasia with the poorest prognosis, due to its high metastatic potential and chemoresistance upon relapse. Using the previously described mouse model for SCLC, we found that the tumors are often composed of phenotypically different cells with either a neuroendocrine or a mesenchymal marker profile. These cells had a common origin because they shared specific genomic aberrations. The transition from neuroendocrine to mesenchymal phenotype could be achieved by the ectopic expression of oncogenic RasV12. Crosstalk between mesenchymal and neuroendocrine cells strongly influenced their behavior. When engrafted as a mixed population, the mesenchymal cells endowed the neuroendocrine cells with metastatic capacity, illustrating the potential relevance of tumor cell heterogeneity in dictating tumor properties.

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Keywords Ras protein, animal experiment, animal model, animal tissue, article, cell heterogeneity, cell population, human, human cell, in vitro study, lung small cell cancer, mesenchyme cell, metastasis, molecular interaction, mouse, mutant protein, neurosecretory cell, nonhuman, phenotype, priority journal, protein Ras V12, protein expression, tumor cell, unclassified drug
Persistent URL dx.doi.org/10.1016/j.ccr.2010.12.021, hdl.handle.net/1765/22819
Citation
Calbo, J, van Montfort, E, Proost, N, van Drunen, E, Beverloo, H.B, Meuwissen, R, & Berns, A. (2011). A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer. Cancer Cell, 19(2), 244–256. doi:10.1016/j.ccr.2010.12.021