Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens
The expression of CD56 antigen in acute promyelocytic leukemia (APL) blasts has been associated with short remission duration and extramedullary relapse. We investigated the clinical significance of CD56 expression in a large series of patients with APL treated with all-trans retinoic acid and anthracycline-based regimens. Between 1996 and 2009, 651 APL patients with available data on CD56 expression were included in 3 subsequent trials (PETHEMA LPA96 and LPA99 and PETHEMA/HOVON LPA2005). Seventytwo patients (11%) were CD56+ (expression of CD56 in ≥20% leukemic promyelocytes). CD56+ APL was significantly associated with high white blood cell counts; low albumin levels; BCR3 isoform; and the coexpression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. For CD56+ APL, the 5-year relapse rate was 22%, compared with a 10% relapse rate for CD56- APL (P = .006). In the multivariate analysis, CD56 expression retained the statistical significance together with the relapse-risk score. CD56+ APLalso showed a greater risk of extramedullary relapse (P < .001). In summary, CD56 expression is associated with the coexpression of immaturity-associated and T-cell antigens and is an independent adverse prognostic factor for relapse in patients with APL treated with all-trans-retinoic acid plus idarubicin - derived regimens. This marker may be considered for implementing riskadapted therapeutic strategies in APL. The LPA2005 trial is registered at http://www.clinicaltrials.gov as NCT00408278.
|Keywords||CD15 antigen, CD2 antigen, CD34 antigen, CD56 antigen, CD7 antigen, HLA DR antigen, T lymphocyte antigen, adult, adverse outcome, aged, albumin, albumin blood level, anthracycline, antigen expression, article, controlled study, cytarabine, extramedullary hematopoiesis, female, human, idarubicin, leukocyte count, major clinical study, male, mitoxantrone, priority journal, prognosis, promyelocytic leukemia, recurrence risk, retinoic acid, stem cell factor receptor|
|Persistent URL||dx.doi.org/10.1182/blood-2010-04-277434, hdl.handle.net/1765/22849|
Montesinos, P., Rayón, C., Vellenga, E., Brunet, S., González, J., González, M., … Löwenberg, B.. (2011). Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. Blood, 117(6), 1799–1805. doi:10.1182/blood-2010-04-277434