Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder
Abstract: Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder. Genetics has an important role in the aetiology of this disease. In this study, we describe the clinical findings in a Dutch family with eight patients suffering from ADHD, in whom five had at least one other psychiatric disorder. We performed a genome-wide (parametric and nonparametric) affected-only linkage analysis. Two genomic regions on chromosomes 7 and 14 showed an excess of allele sharing among the definitely affected members of the family with suggestive LOD scores (2.1 and 2.08). Nonparametric linkage analyses (NPL) yielded a maxNPL of 2.92 (P=0.001) for marker D7S502 and a maxNPL score of 2.56 (P=0.003) for marker D14S275. We confirmed that all patients share the same haplotype in each region of 7p15.1-q31.33 and 14q11.2-q22.3. Interestingly, both loci have been reported before in Dutch (affected sib pairs) and German (extended families) ADHD linkage studies. Hopefully, the genome-wide association studies in ADHD will help to highlight specific polymorphisms and genes within the broad areas detected by our, as well as other, linkage studies.
|Keywords||*Chromosomes, Human, Pair 14, *Chromosomes, Human, Pair 7, Attention Deficit Disorder with Hyperactivity/*genetics, Chromosome Aberrations, Chromosome Mapping, Comorbidity, Female, Genetic Markers, Genome-Wide Association Study/*methods, Haplotypes/genetics, Humans, Male, Microsatellite Repeats/genetics, Netherlands, Pedigree|
|Persistent URL||dx.doi.org/10.1038/ejhg.2009.148, hdl.handle.net/1765/23079|
|Journal||European Journal of Human Genetics|
Vegt, M, Bertoli Avella, A.M, Tulen, J.H.M, de Graaf, B.M, Verkerk, J.H.M, Vervoort, J, … Oostra, B.A. (2010). Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder. European Journal of Human Genetics, 18(2), 206–211. doi:10.1038/ejhg.2009.148