Mycophenolate mofetil in kidney transplantation
Mycophenolate mofetil is a new immunosupressive drug, exhibiting its effect through inhibition of proliferation ofT- and B-Iymphocytes. Superior efficacy of mycophenolate mofetil compared to azathioprine, in combination with cyclosporine and prednisone, in the prevention of acute rejection in organ transplantation has made mycophenolate mofetil one of the standard immunosupressive drugs after transplantation. Mycophenolate mofetil also is an interesting candidate drug for many other, mainly auto-immune mediated diseases. The use of mycophenolate mofetil in several of these diseases is discussed. The defmitive place of mycophenolate mofetil will depend on the results of randomised trials currently under way.
|Keywords||kidney transplantation, mycophenolate mofetil, organ transplantattion, pharmacokinetics, pharmacology|
|Promotor||Weimar, W. (Willem)|
|Sponsor||Dutch Kidney Foundation (Nierstichting Nederland), Roche Pharmaceuticals (Mijdrecht, the Netherlands)|
|Publisher||Erasmus MC: University Medical Center Rotterdam|
Smak Gregoor, P.J.H.. (2001, May 23). Mycophenolate mofetil in kidney transplantation. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/23400