Effect of oxandrolone on glucose metabolism in growth hormone-treated girls with turner syndrome
Background: The weak androgen oxandrolone (Ox) may increase height but may also affect glucose metabolism in girls with Turner syndrome (TS). Methods: In a randomized, placebo-controlled, double-blind study, we assessed the effect of Ox at a dosage of either 0.06 or 0.03 mg/kg/day on glucose metabolism in 133 growth hormone (GH)-treated girls with TS. Patients were treated with GH (1.33 mg/m2/day) from baseline, combined with placebo (Pl) or Ox from the age of 8, and estrogens from the age of 12. Oral glucose tolerance tests (OGTT) were performed, and HbA1c levels were measured before, during, and after discontinuing Ox/Pl therapy. Results: Insulin sensitivity, assessed by the whole-body insulin sensitivity index (WBISI) decreased during GH+Ox/Pl (p = 0.003) without significant differences between the dosage groups. Values returned to pre-treatment levels after discontinuing GH+Ox/Pl. On GH+Ox, fasting glucose was less frequently impaired (Ox 0.03, p = 0.001; Ox 0.06, p = 0.02) and HbA1c levels decreased more (p = 0.03 and p = 0.001, respectively) than on GH+Pl. Conclusions: We conclude that in GH-treated girls with TS, Ox at a dosage of 0.03 or 0.06 mg/kg/day does not significantly affect insulin sensitivity. Insulin sensitivity decreases during GH therapy, to return to a pre-treatment level after discontinuing therapy.
|Keywords||Carbohydrate metabolism, Estrogen replacement therapy, Growth hormone therapy, Oxandrolone, Turner syndrome, adolescent, article, bedtime dosage, child, double blind procedure, drug dose increase, drug effect, drug withdrawal, estradiol, ethinylestradiol, female, glucose, glucose metabolism, growth hormone, hemoglobin A1c, human, insulin, insulin sensitivity, major clinical study, oral glucose tolerance test, oxandrolone, placebo, preschool child, priority journal, randomized controlled trial, school child|
|Persistent URL||dx.doi.org/10.1159/000319313, hdl.handle.net/1765/23491|
|Journal||Hormone Research in Paediatrics|
Menke, L.A, Sas, T.C.J, Stijnen, Th, Zandwijken, G.R.J, de Muinck Keizer-Schrama, S.M.P.F, Otten, B.J, & Wit, J.M. (2011). Effect of oxandrolone on glucose metabolism in growth hormone-treated girls with turner syndrome. Hormone Research in Paediatrics, 75(2), 115–122. doi:10.1159/000319313