university website

J-P. Julien (Jean-Pierre), K. Ramachadran and F.G. Grosveld (Frank)

1985

Cloning of a cDNA encoding the smallest neurofilament protein from the rat

Publication

Publication

B B A - Proteins and Proteomics , Volume 825 p. 398- 404

We have cloned a cDNA coding for the smallest rat neurofilament protein. The cDNA is 861 nucleotides long coding for 287 amino acids from the internal alpha-helical region and the carboxy-terminal tail domain of the neurofilament protein. Comparison of the porcine, mouse and rat neurofilament protein sequences shows that the protein is highly conserved (greater than 93% identity). Blot analysis indicates that the cDNA is derived from a single neurofilament gene that codes for two different poly(A)+ mRNA species.

Additional Metadata
Keywords 0 (Intermediate Filament Proteins), 0 (Nerve Tissue Proteins), 0 (Neurofilament Proteins), 0 (Oligodeoxyribonucleotides), 0 (RNA, Messenger), 9007-49-2 (dna), Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA/genetics, Genes, Structural, Intermediate Filament Proteins/*genetics, Molecular Weight, Nerve Tissue Proteins/*genetics, Neurofilament Proteins, Oligodeoxyribonucleotides/diagnostic use, RNA, Messenger/genetics, Rats, Support, Non-U.S. Gov't, Transcription, Genetic
Persistent URL hdl.handle.net/1765/2389
Journal B B A - Proteins and Proteomics
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Julien, J.-P., Ramachadran, K., & Grosveld, F. (1985). Cloning of a cDNA encoding the smallest neurofilament protein from the rat. B B A - Proteins and Proteomics, 825, 398–404. Retrieved from http://hdl.handle.net/1765/2389
Free Full Text ( Final Version , 5mb ) cover


User Publication Person Organisation Collection
Close