Structure of the murine Thy-1 gene
We have cloned the murine Thy-1.1 (AKR) and Thy-1.2 (Balb/c) genes. The complete exon/intron structure and the nucleotide sequence of the Thy-1.2 gene was determined. The gene contains four exons and three intervening sequences. The complete transcriptional unit gives rise to a tissue and developmental stage-specific mRNA of 1850 bp. The 5' end of the gene has multiple initiation sites and a non-TATA box promoter. The 3' end shows a single polyadenylation site after a very long untranslated region.
|Keywords||*Cloning, Molecular, *Genes, Structural, 0 (Antigens, Surface), 0 (Antigens, Thy-1), 0 (Plasmids), 0 (RNA, Messenger), 9007-49-2 (dna), Amino Acid Sequence, Animals, Antigens, Surface/*genetics, Antigens, Thy-1, Base Sequence, Comparative Study, DNA Restriction Enzymes, DNA/*analysis, EC 3.1.21 (DNA Restriction Enzymes), Hela Cells, Human, Mice, Mice, Inbred Strains, Plasmids, RNA, Messenger/genetics, Rats, Species Specificity, Support, Non-U.S. Gov't, Transcription, Genetic, Transfection|
Giguere, V., Isobe, K-I., & Grosveld, F.G.. (1985). Structure of the murine Thy-1 gene. EMBO Journal, 4, 2017–2024. Retrieved from http://hdl.handle.net/1765/2392