In earlier work, we suggested that the start of the isovolumic contraction period could be detected in arterial pressure waveforms as the start of a temporary pre-systolic pressure perturbation (AICstart, start of the Arterially detected Isovolumic Contraction), and proposed the retrograde coronary blood volume flow in combination with a backwards traveling pressure wave as its most likely origin. In this study, we tested this hypothesis by means of a coronary artery occlusion protocol. In six Yorkshire × Landrace swine, we simultaneously occluded the left anterior descending (LAD) and left circumflex (LCx) artery for 5 s followed by a 20-s reperfusion period and repeated this sequence at least two more times. A similar procedure was used to occlude only the right coronary artery (RCA) and finally all three main coronary arteries simultaneously. None of the occlusion protocols caused a decrease in the arterial pressure perturbation in the aorta during occlusion (P > 0.20) nor an increase during reactive hyperemia (P > 0.22), despite a higher deceleration of coronary blood volume flow (P = 0.03) or increased coronary conductance (P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries.

Additional Metadata
Keywords Coronary occlusion, Coronary-aortic interaction, Isovolumic contraction, Pulse wave analysis
Persistent URL dx.doi.org/10.1007/s11517-011-0770-y, hdl.handle.net/1765/24034
Citation
van Houwelingen, M.J., Merkus, D., te Lintel Hekkert, M., van Dijk, G., Hoeks, A.P.G., & Duncker, D.J.G.M.. (2011). Coronary-aortic interaction during ventricular isovolumic contraction. Medical & Biological Engineering & Computing, 49, 917–924. doi:10.1007/s11517-011-0770-y