1987
Differential regulation of a Thy-1 gene in transgenic mice.
Publication
Publication
Proceedings of the National Academy of Sciences of the United States of America p. 1492- 1496
We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but not the endogenous gene, was suppressed. This result shows that different regulatory elements are used to express the Thy-1 gene in early and late lymphoid development.
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hdl.handle.net/1765/2411 | |
Proceedings of the National Academy of Sciences of the United States of America | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Kollias, G., Spanopoulou, E., Grosveld, F., Ritter, M., Beech, J., & Morris, R. (1987). Differential regulation of a Thy-1 gene in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 1492–1496. Retrieved from http://hdl.handle.net/1765/2411 |