Purpose: This study aims to increase knowledge of colorectal anastomotic leakage by performing an incidence study and risk factor analysis with new potential risk factors in a Dutch tertiary referral center. Methods: All patients whom received a primary colorectal anastomosis between 1997 and 2007 were selected by means of operation codes. Patient records were studied for population description and risk factor analysis. Results: In total 739 patients were included. Anastomotic leakage (AL) occurred in 64 (8.7%) patients of whom nine (14.1%) died. Median interval between operation and diagnosis was 8 days. The risk for AL was higher as the anastomoses were constructed more distally (p = 0.019). Univariate analysis showed duration of surgery (p = 0.038), BMI (p = 0.001), time of surgery (p = 0.029), prophylactic drainage (p = 0.006) and time under anesthesia (p = 0.012) to be associated to AL. Multivariate analysis showed BMI greater than 30 kg/m2(p = 0.006; OR 2.6 CI 1.3-5.2) and "after hours" construction of an anastomosis (p = 0.030; OR 2.2 CI 1.1-4.5) to be independent risk factors. Conclusion: BMI greater than 30 kg/m2and "after hours" construction of an anastomosis were independent risk factors for colorectal anastomotic leakage.

Additional Metadata
Keywords After-hours, Anastomotic leakage, Body mass index, Colorectal surgery
Persistent URL dx.doi.org/10.1007/s00384-009-0692-4, hdl.handle.net/1765/24174
Komen, N.A.P, Dijk, J-W, Lalmahomed, Z.S, Klop, K.W.J, Hop, W, Kleinrensink, G.J, … Lange, J.F. (2009). After-hours colorectal surgery: A risk factor for anastomotic leakage. International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery, 24(7), 789–795. doi:10.1007/s00384-009-0692-4