2009-05-01
Outcome of radiotherapy in T1 glottic carcinoma: A population-based study
Publication
Publication
European Archives of Oto-Rhino-Laryngology , Volume 266 - Issue 5 p. 735- 744
We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.
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| , , , , , , | |
| doi.org/10.1007/s00405-008-0803-9, hdl.handle.net/1765/24179 | |
| European Archives of Oto-Rhino-Laryngology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Sjögren, E., Wiggenraad, R., le Cessie, S., Snijder, S., Pomp, J., & de Jong, R. J. B. (2009). Outcome of radiotherapy in T1 glottic carcinoma: A population-based study. European Archives of Oto-Rhino-Laryngology, 266(5), 735–744. doi:10.1007/s00405-008-0803-9 |
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