1987
Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.
Publication
Publication
Cell , Volume 51 p. 21- 31
Hybrid human--mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5' part of the mouse Thy-1.1 gene combined with the 3' human untranslated regions was expressed abnormally in the kidney podocytes, which resulted in severe protein-uria and subsequent death in several founder mice. A hybrid Thy-1 gene composed of the human coding region with the 5' and 3' flanking regions of the mouse gene was expressed abnormally in a different part of the kidney (the tubular epithelia), which resulted in a proliferative kidney disorder. In addition, a neoplasm was found in the brain of one of these mice. These results show that the Thy-1 protein can play an important role in the activation, proliferation, and differentiation of many different cell types.
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hdl.handle.net/1765/2423 | |
Cell | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Kollias, G., Evans, D., Ritter, M., Beech, J., Morris, R., & Grosveld, F. (1987). Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell, 51, 21–31. Retrieved from http://hdl.handle.net/1765/2423 |