The transcriptional unit of the murine Thy-1 gene unit: Differential distribution of transcription initiation sites in brain.
Structural analysis of the mouse Thy-1.2 gene has shown that the major promoter of the gene is characterized by a tissue-specific DNase I-hypersensitive site and is located within a methylation-free island. The gene is regulated at the transcriptional level, and steady-state mRNA analysis reveals that the previously reported exon Ib contributes at most 5% of the total mRNA. The major promoter uses several transcription initiation sites within a region of 100 base pairs. The frequency of usage of these sites in brain is markedly different from that in other tissues.
|Keywords||*Genes, Structural, *Transcription, Genetic, 0 (Antigens, Surface), 0 (Antigens, Thy-1), 0 (Chromatin), Animals, Antigens, Surface/*genetics, Antigens, Thy-1, Base Sequence, Blotting, Northern, Brain/*metabolism, Chromatin/ultrastructure, DNA Restriction Enzymes, Deoxyribonuclease I, EC 3.1.21 (DNA Restriction Enzymes), EC 126.96.36.199 (Deoxyribonuclease I), Exons, Mice, Mice, Inbred Strains, Molecular Sequence Data, Nucleotide Mapping, Support, Non-U.S. Gov't|
Spanopoulou, E., Giguere, V., & Grosveld, F.G.. (1988). The transcriptional unit of the murine Thy-1 gene unit: Differential distribution of transcription initiation sites in brain.. Molecular and Cellular Biology, 8, 3847–3856. Retrieved from http://hdl.handle.net/1765/2429