We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10 11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10 11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10 8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

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Persistent URL dx.doi.org/10.1038/ng.387, hdl.handle.net/1765/24579
Citation
Stolk, L., Zhai, G., van Meurs, J.B.J., Verbiest, M., Visser, J.A., Estrada Gil, K., … Uitterlinden, A.G.. (2009). Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nature Genetics, 41(6), 645–647. doi:10.1038/ng.387