Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10-11; combined RR = 1.25; combined P = 1.8 × 10-15).
|Persistent URL||dx.doi.org/10.1038/ng.416, hdl.handle.net/1765/24581|
Benjamin, E.J., Rice, K., Arking, D.E., Pfeufer, A., van Noord, C., Smith, A.V., … Witteman, J.C.M.. (2009). Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. Nature Genetics, 41(8), 879–881. doi:10.1038/ng.416