Background:Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse.Method:The aim of this study was to compare tumour stage and survival of IBD patients with CRC who were a part of a surveillance programme with those who were not. A nationwide pathology database (PALGA (pathologisch anatomisch landelijk geautomatiseerd archief)) was consulted to identify IBD patients with CRC treated in all eight university hospitals in The Netherlands over a period of 15 years. Patients were assigned to the surveillance group when they had undergone one or more surveillance colonoscopies before a diagnosis of CRC. Patients who had not undergone surveillance served as controls. Tumour stage and survival were compared between the two groups.Results:A total of 149 patients with IBD-associated CRC were identified. Twenty-three had had colonoscopic surveillance before CRC was discovered. The 5-year CRC-related survival rate of patients in the surveillance group was 100% compared with 74% in the non-surveillance group (P0.042). In the surveillance group, only one patient died as a consequence of CRC compared with 29 patients in the control group (P0.047). In addition, more early tumour stages were found in the surveillance group (P0.004).Conclusions:These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.

Additional Metadata
Keywords CRC, Colorectal cancer, IBD, Inflammatory bowel disease, Surveillance, Survival, Tumour stage
Persistent URL dx.doi.org/10.1038/sj.bjc.6605359, hdl.handle.net/1765/24591
Citation
Lutgens, M.W.M.D., Oldenburg, B., Siersema, P.D., van Bodegraven, A.A., Dijkstra, G., Hommes, D.W., … Vleggaar, F.P.. (2009). Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease. British Journal of Cancer, 101(10), 1671–1675. doi:10.1038/sj.bjc.6605359