1991
The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16.
Publication
Publication
Immunology: the journal of cells, molecules, system and technologies , Volume 72 p. 213- 218
There is much evidence to suggest that potentially immunogenic tumour cells can escape cytolytic immune destruction by loss of class I antigen expression. Many tumours are allele-specific class I negative and, in murine systems, reconstitution of class I expression by gene transfection leads to an increase in tumour immunogenicity. In many systems where mice have rejected class I transfected tumour cells they are also immune to a subsequent challenge with the untransfected parent tumour. In this study we have examined the effect of stable class II antigen expression (induced by gene transfection) on a class I loss mutant (H-2Kk negative) murine cell line, K36.16. We show that H-2Ek expression is more effective at increasing tumour immunogenicity than the reconstitution of H-2Kk expression in these cells. This suggests that the induction of class II antigen expression on tumour cells may provide an effective way of enhancing tumour-specific immune responses in vivo.
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hdl.handle.net/1765/2465 | |
Immunology: the journal of cells, molecules, system and technologies | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
James, R. F. L., Edwards, S., Hui, K. M., Bassett, P. D., & Grosveld, F. (1991). The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16. Immunology: the journal of cells, molecules, system and technologies, 72, 213–218. Retrieved from http://hdl.handle.net/1765/2465 |