Background: A previous limited study showed promising results of combined oral treatment with rifampicin 600 mg and clindamycin 600 mg for 10 weeks. Objective: To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations. Method: A retrospective study in 34 patients. Results: Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease. Conclusion: Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established. Copyright

Additional Metadata
Keywords Acne inversa, Antibiotics therapy, Clindamycin, Rifampicin
Persistent URL dx.doi.org/10.1159/000228337, hdl.handle.net/1765/24929
Citation
van der Zee, H.H., Boer, J., Prens, E.P., & Jemec, G.B.E.. (2009). The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa. Dermatology: international journal for clinical and investigative dermatology, 219(2), 143–147. doi:10.1159/000228337