university website

F.G. Grosveld (Frank), M.G.J.M. Wijgerde (Mark) and P.J. Fraser (Peter)

1995

Transcription complex stability and chromatin dynamics in vivo.

Publication

Publication

Nature: international weekly journal of science , Volume 377 p. 209- 213

Distant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism.

Additional Metadata
Keywords *Gene Expression Regulation, Developmental, *Regulatory Sequences, Nucleic Acid, *Transcription, Genetic, 0 (Chromatin), 9004-22-2 (Globins), Animals, Cell Cycle, Chromatin/*metabolism, DNA Replication, Globins/*genetics, Human, In Situ Hybridization, Liver/cytology/embryology/metabolism, Mice, Mice, Transgenic, Support, Non-U.S. Gov't, Time Factors
Persistent URL hdl.handle.net/1765/2509
Journal Nature: international weekly journal of science
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Grosveld, F., Wijgerde, M., & Fraser, P. (1995). Transcription complex stability and chromatin dynamics in vivo. Nature: international weekly journal of science, 377, 209–213. Retrieved from http://hdl.handle.net/1765/2509
Free Full Text ( Final Version , 1mb ) cover


User Publication Person Organisation Collection
Close