Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+and CD34+cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
|Keywords||Angiotensin, CD34, Hematopoietic stem cell|
|Persistent URL||dx.doi.org/10.3324/haematol.2008.000034, hdl.handle.net/1765/25438|
Heringer-Walther, S., Eckert, K., Schumacher, S.M., Uharek, L., Wulf-Goldenberg, A., Gembardt, F., … Walther, T.. (2009). Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo. Haematologica, 94(6), 857–860. doi:10.3324/haematol.2008.000034