Objective: To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds. Design: Population-based, cross-sectional analysis. Setting: The Rotterdam Scan Study. Participants: A total of 198 persons (age range, 61-95 years) with lobar microbleeds. Main Outcome Measures: Distribution of microbleeds over different lobes. Results:Wefoundthat lobar cerebralmicrobleedsoccurred significantlymoreoften inthetemporallobe, aregionknown to be more affected in cerebral amyloid angiopathy. Conclusion: This study corroborates the presumed association of lobar microbleeds with cerebral amyloid angiopathy.

doi.org/10.1001/archneurol.2011.93, hdl.handle.net/1765/25802
Archives of Neurology
Erasmus MC: University Medical Center Rotterdam

Mesker, D. J., Poels, M., Ikram, A., Vernooij, M., Hofman, A., Vrooman, H., … Breteler, M. (2011). Lobar distribution of cerebral microbleeds: The Rotterdam Scan Study. Archives of Neurology, 68(5), 656–659. doi:10.1001/archneurol.2011.93