N -acetylaspartylglutamate in CNS hypomyelination
CSF N-acetylaspartylglutamate (NAAG) has been found to be elevated in some hypomyelinating disorders. This study addressed the question whether it could be used as a marker for hypomyelination and as a means to distinguish between hypomyelinating disorders biochemically. We have measured CSF NAAG in a cohort of 28 patients with hypomyelination with known and unknown aetiology. NAAG was found to be elevated in 7 patients, but was normal in the majority, including patients with defined hypomyelinating disorders. CSF NAAG is not a universal marker of hypomyelination, and the mechanism of its elevation remains poorly understood.
|Keywords||N -acetylaspartylglutamate, hypomyelination, white matter disorder|
|Persistent URL||dx.doi.org/10.1055/s-0031-1277176, hdl.handle.net/1765/26551|
Wamelink, M.M.C., Struys, E., Holwerda, U., Sistermans, E.A., van Spaendonk, R.M.L., Halley, D.J.J., … Wolf, N.I.. (2011). N -acetylaspartylglutamate in CNS hypomyelination. Neuropediatrics, 42(2), 74–77. doi:10.1055/s-0031-1277176