Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma
Background: The prognosis of T-cell lymphoma is poor. To explore the addition of the monoclonal antibody alemtuzumab, we studied the efficacy and tolerability of an intensified alemtuzumab-chemotherapy combination for aggressive T-cell lymphoma in a phase II study by Dutch-Belgian Hemato-Oncology Group (HOVON). Patients and methods: Patients (≤65 years) with newly diagnosed T-cell lymphoma received eight CHOP cycles (cyclophosphamide, doxorubicin, vincristine, prednisone) 2-weekly, each cycle with three doses of 30 mg alemtuzumab. Prophylaxis consisted of cotrimoxazole, fluconazole and valaciclovir. Cytomegalovirus (CMV) monitoring took place at least every fortnight. Results: Twenty patients from 10 centers, median age 50 years, were included. Eighty-five percent received six or more cycles. The overall response was 90% [12 complete remissions (CRs), 1 CR unconfirmed, 5 partial remissions]. Median duration of follow-up of patients still alive was 29 months (range 19-41 months). Median overall survival (OS) and event-free survival (EFS) were 27 and 10 months, with 55%/27% OS/EFS at 2 years. Adverse events consisted of neutropenic fever (n = 8) and CMV reactivation (n = 7), with one CMV disease. Three patients developed secondary Epstein-Barr virus (EBV)-related lymphoma, all after end of treatment. Conclusions: Although intensified alemtuzumab-CHOP induces high responses, many patients relapse, and the scheme is associated with serious infection-related adverse events. EBV monitoring after end of treatment is required.
|Keywords||Alemtuzumab, EBV, Immunochemotherapy, T-cell lymphoma, T-cell non-Hodgkin's lymphoma|
|Persistent URL||dx.doi.org/10.1093/annonc/mdq635, hdl.handle.net/1765/26552|
Kluin-Nelemans, H.C., van Marwijk Kooy, M., Lugtenburg, P.J., van Putten, W.L.J., Luten, M., Oudejans, J., & van Imhoff, G.. (2011). Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma. Annals of Oncology, 22(7), 1595–1600. doi:10.1093/annonc/mdq635