Based on previous epidemiologic studies it is estimated that in the Netherlands the referral based prevalence of moderate to severe von Willebrand disease (VWD) is approximately 1 in 10,000 (1650 patients). This does not include patients with mild type 1 disease (VWF levels 30-50 U/dL), or individuals with borderline VWF levels with a mild bleeding phenotype, of which the prevalence is higher and may even reach 1:100 individuals. Despite the frequency of the disease only a limited number of studies have been performed on clinical presentation, determinants of bleeding phenotype and Quality of Life (QoL). Therefore we have initiated a nationwide study on moderate and severe VWD in the Netherlands, the Willebrand in the Netherlands study, the WiN study.

Additional Metadata
Keywords Netherlands, Willebrand disease, bleeding disorder, haemophilia
Promotor F.W.G. Leebeek (Frank)
Publisher Erasmus University Rotterdam
Sponsor CSL Behring , Stichting Haemophilia
ISBN 978-90-9026169-0
Persistent URL hdl.handle.net/1765/26746
Citation
de Wee, E.M.. (2011, October 26). Von Willebrand Disease in the Netherlands. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/26746