Objectives: To unravel the extent to which gender plays a role in the epidemiology, aetiology, risk of rupture and treatment of abdominal aortic aneurysms (AAAs) and to give an overview of these factors. Design, Materials and Methods: A literature review was performed in the Medline database and Cochrane Library for gender-specific articles on epidemiology, aetiology, risk of rupture and treatment of AAAs. Results: Our literature review suggests that the prevalence of AAA in women is underestimated. Regarding aetiology, an oestrogen-mediated reduction in macrophage MMP-9 production seems to be an important mechanism causing gender-related differences in AAA development. We found consensus in the literature that women run a greater risk of rupture compared to men under the current management rules for AAAs. Their treatment mortality also seems to be higher for both elective and ruptured repair. Conclusions: Gender-specific guidelines should be put into place for the management of AAAs and awareness for this disease should be increased, both in women themselves and in their doctors.

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Keywords Abdominal aortic aneurysm, Aetiology, Epidemiology, Gender, Rupture, Treatment
Persistent URL dx.doi.org/10.1016/j.ejvs.2009.05.004, hdl.handle.net/1765/27001
Grootenboer, N., Bosch, J.L.H.R., Hendriks, J.M., & van Sambeek, M.R.H.M.. (2009). Epidemiology, Aetiology, Risk of Rupture and Treatment of Abdominal Aortic Aneurysms: Does Sex Matter?. European Journal of Vascular and Endovascular Surgery, 38(3), 278–284. doi:10.1016/j.ejvs.2009.05.004