2010-11-12
Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association
Publication
Publication
Biochemical and Biophysical Research Communications , Volume 402 - Issue 2 p. 203- 208
Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments using gene-knockdown we could indeed confirm this and furthermore we asserted CHCHD10 to play a role in complex IV activity.
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| doi.org/10.1016/j.bbrc.2010.09.109, hdl.handle.net/1765/27490 | |
| Biochemical and Biophysical Research Communications | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Martherus, R., Sluiter, W., Timmer, E., VanHerle, S., Smeets, H., & Ayoubi, T. (2010). Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association. Biochemical and Biophysical Research Communications, 402(2), 203–208. doi:10.1016/j.bbrc.2010.09.109 |
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