Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.

Additional Metadata
Keywords Asthma, DC, Influenza, Lung, T-cell polarization
Persistent URL dx.doi.org/10.1002/eji.201040562, hdl.handle.net/1765/27681
Citation
Plantinga, M, Hammad, H, & Lambrecht, B.N.M. (2010). Origin and functional specializations of DC subsets in the lung. European Journal of Immunology, 40(8), 2112–2118. doi:10.1002/eji.201040562