Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4+T cells in the pathogenesis of Hu-PNS.

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Keywords HLA, Hu-antibodies, Paraneoplastic neurological syndromes, SCLC
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de Graaf, M.T, de Beukelaar, J.W.K, Haasnoot, G.W, Levering, W.H.B.M, Rogemond, V, Didelot, A, … Smitt, P.A. (2010). HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. Journal of Neuroimmunology, 226(1-2), 147–149. doi:10.1016/j.jneuroim.2010.05.035