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M.T. de Graaf (Marieke), J.W.K. de Beukelaar (Janet), G.W. Haasnoot (Geert), W.H.B.M. Levering, V. Rogemond (Veronique), A. Didelot (Adrien), J. Honnorat (Jerôme), J.W. Gratama (Jan-Willem) and P.A. Smitt (Peter)

2010-09-01

HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Publication

Publication

Journal of Neuroimmunology , Volume 226 - Issue 1-2 p. 147- 149

Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4+T cells in the pathogenesis of Hu-PNS.

Additional Metadata
Keywords HLA, Hu-antibodies, Paraneoplastic neurological syndromes, SCLC
Persistent URL doi.org/10.1016/j.jneuroim.2010.05.035, hdl.handle.net/1765/27732
Journal Journal of Neuroimmunology
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
de Graaf, M., de Beukelaar, J., Haasnoot, G., Levering, W. H. B. M., Rogemond, V., Didelot, A., … Smitt, P. (2010). HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. Journal of Neuroimmunology, 226(1-2), 147–149. doi:10.1016/j.jneuroim.2010.05.035


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