Aims Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. Methods and resultsA total of 64 patients (34 male, mean age 61 ± 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect ≥50 luminal narrowing on a patient basis were 100, 88, 92, and 100, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect ≥70 luminal narrowing on a patient basis were 94, 95, 88, and 98, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect ≥50 luminal narrowing on a patient basis were 100, 81, 88, and 100, respectively. Conclusion The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.

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Keywords Cardiac imaging, Coronary angiography, Multidetector computed tomography
Persistent URL dx.doi.org/10.1093/eurheartj/ehp571, hdl.handle.net/1765/27797
Note Free full text at PubMed
Citation
de Graaf, F.R., Schuijf, J.D., van Velzen, J.E., Kroft, L.J., de Roos, A., Reiber, J.H.C., … Bax, J.J.. (2010). Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease. European Heart Journal, 31(15), 1908–1915. doi:10.1093/eurheartj/ehp571